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Career | Senior Director, Financial Planning and Analysis (FP&A) | Encoded Therapeutics

Senior Director, Financial Planning and Analysis (FP&A)

Encoded Therapeutics

South San Francisco, CA, US / Onsite/Remote

Job Type: Full-Time
Function: Accounting/Finance
Industry: Health Tech
Post Date: 06/03/2026
Website: encoded.com
Company Address: 341 Oyster Point Blvd, South San Francisco, California 94080, US

About Encoded Therapeutics

Encoded Therapeutics is creating one-time, disease-modifying gene therapies for pediatric central nervous system (CNS) disorders with its cell-selective targeting and regulation platform.

Job Description

Encoded Therapeutics is a clinical-stage biotechnology company developing precision genetic medicines to transform the lives of patients with severe neurological disorders. The company’s vector engineering platform enables potent and cell-type-selective regulation of gene expression, allowing for targeted modulation of disease-relevant genes. Encoded is advancing a pipeline of programs across genetic epilepsies and other neurological disorders with significant unmet need. With integrated discovery, development, and manufacturing capabilities, Encoded is positioned to efficiently move programs from concept through the clinic. Encoded is driven by a mission to meaningfully improve the lives of patients and families affected by devastating neurological disorders. For more information, please visit .

We are seeking a high-caliber Senior Director, FP&A to serve as a strategic architect of our financial roadmap. You will be the primary bridge between clinical innovation and financial sustainability. Not only will you manage the numbers but also synthesize complex data into actionable insights for the Leadership Team and Board of Directors, directly influencing the company’s overall business strategy and clinical program investments.

This role is based in South San Francisco and reports to the Vice President, Finance.

Responsibilities:

Strategic Financial Planning: Lead end-to-end annual operating plan, quarterly forecasting (Latest Estimate), Long Range Plan and Scenario Planning processes. Conduct rigorous sensitivity and risk analyses to guide executive decision-making. Establish Commercial Planning process, including P&L modeling, demand planning and competitive analysis.

R&D CMC Business Partnership: Act as the dedicated finance lead for R&D and Manufacturing functions. Collaborate on complex clinical study accruals and build robust modeling frameworks to track program-level performance against budgets.
Corporate Dashboards & KPIs: Develop and maintain corporate dashboards to track performance against key clinical, program, and operational milestones.
Infrastructure Scaling: Build out the FP&A team’s infrastructure to enable flexible forecast modeling, streamlined management reporting, cash forecasting and clinical trial study analytics and reporting
Corporate Development Support: Provide financial modeling and due diligence support for M&A, licensing, and clinical investment decisions
Cross-Functional Stewardship: Serve as the financial gatekeeper for contract requests via Coupa and act as the primary System Administrator for Adaptive, ensuring the integrity of our planning tools
Governance & Compliance: Advise internal stakeholders on corporate policies and compliance to ensure proper GAAP treatment of expenses throughout the organization.

Requirements

Education: Bachelor’s Degree required, Master's degree preferred.
Experience: 15+ years of progressive financial management experience, 5+ years building and managing high-performing teams.
Industry Expertise: Proven experience in the Biotech/Life Science industry, specifically R&D, Clinical Trial, and Commercial Planning.
Systems and Tools: Proficiency with NetSuite, Coupa and Adaptive required.
Communication: Strong verbal and written communication skills with previous experience supporting BoD level audiences.
Leadership: Strong ability to lead through change and communicate complex financial concepts to diverse stakeholders.

For candidates based in the SFB area, the salary range for this position is: $250,000 to $290,000.

Benefits

Comprehensive benefits package, including competitive employer premium contributions
Meaningful stock option grants
PTO, sick time, and holiday pay
Generous Parental Leave program
Pre-tax medical and dependent care programs
STD, LTD, Life and AD&D
Professional development opportunities
Team-building events
Fully stocked kitchen
Fitness center at our SF office

Employees (and their families) may obtain medical, dental, vision and basic life insurance benefits through the company and enroll in our company’s 401k plan. Employees will also accrue vacation time off and paid sick time off and may become eligible for paid parental leave. Employees will also enjoy designated paid holidays throughout the calendar year.

Encoded is an Equal Opportunity Employer and prohibits discrimination and harassment of any kind. Encoded is committed to the principle of equal employment opportunity for all employees and to providing employees with a work environment free of discrimination and harassment. All employment decisions at Encoded are based on business needs, job requirements and individual qualifications, without regard to race, religion or belief, color, national origin, gender, status as a protected veteran, status as an individual with a disability, or any other status protected by the laws or regulations in the location in which we operate. Encoded will not tolerate discrimination or harassment based on any of these characteristics. Encoded encourages applicants of all ages.

If you need assistance or an accommodation due to a disability, you may call us at +1 650-491-0272.