Senior Director, Global HEOR and Evidence Generation
Encoded Therapeutics
- Job Type: Full-Time
- Function: HR
- Industry: Health Tech
- Post Date: 02/10/2026
- Website: encoded.com
- Company Address: 341 Oyster Point Blvd, South San Francisco, California 94080, US
About Encoded Therapeutics
Encoded Therapeutics is creating one-time, disease-modifying gene therapies for pediatric central nervous system (CNS) disorders with its cell-selective targeting and regulation platform.Job Description
ETX101 is a single-administration, potentially transformative intervention. As such, this individual understands global evidence needs and will be responsible for developing a sophisticated, long-term value evidence package for global stakeholders, and for designing and implementing effective solutions that optimize value and access discussions. This is a high-impact role for an individual who thrives on translating vision into execution within a fast-evolving and innovative environment.
Responsibilities:
- Strategic planning and implementation: Define and lead the global HEOR roadmap for ETX101, ensuring that strategies drive creation of a strong value story for ETX101 to optimize payer and HTA engagement in alignment with clinical, regulatory and commercial readiness timelines and plans.
- Integrated evidence generation: Serve as a key internal expert supporting design of Encoded’s clinical development program to maximize their utility both for regulatory authorities and payers. Design and execute specific studies, including burden-of-illness (BOI; clinical, humanistic, economic), real-world evidence, and patient preference studies. Support development and/or validation of clinically meaningful outcome measures. Oversee development of cost-utility analyses and budget impact modelling.
- Stakeholder engagement: Partner with clinical experts, the patient community, HTA bodies/payers, and other external collaborators to disseminate accurate information across channels, including publications, congresses, and symposia.
- Operational excellence: Manage vendor selection, budgets, and resource allocation for complex HEOR projects, ensuring timely completion and, in concert with Scientific Communications, high-impact delivery of abstracts, posters, and manuscripts.
- Cross-functional support: Contribute to or lead other cross-functional initiatives, as needed, including Medical Affairs, Market Access and Commercial activities (e.g. payer/HTA research, value messaging, launch roadmaps, and CoE and patient journey mapping) to ensure development of innovative approaches that address the unique opportunities and challenges of gene therapy.
- Travel domestically and internationally, as required.
Requirements
- Education: PhD, PharmD, or MD with 10–12+ years of experience in HEOR within the biotech/pharma industry.
- Deep technical knowledge of the unique value drivers for high-cost, one-time therapies and the global HTA landscape (e.g., ICER, NICE, G-BA, JCA).
- Understanding of medical terminology, statistical concepts, and the ability to oversee complex observational research studies and cost-effectiveness modelling.
- Exceptional written and verbal communication skills, capable of presenting technical data to payers, investors, and clinical experts.
- Strong project management, and proven success managing multiple complex projects simultaneously in a fast-paced environment
- Direct experience of identifying and managing consultants, agencies, or other vendors
- Excellent written and verbal communication, negotiation, and presentation skills
- Strong interpersonal skills and ability to communicate across all levels of the organization
- Familiarity with gene therapy, rare diseases, or CNS indications preferred
- Proven understanding of medical terminology and statistical concepts
Preferred Qualifications:
- Proven success in a startup environment, with the ability to build functions from the ground up and manage multiple complex projects simultaneously.
- Experience in rare/orphan diseases, epilepsy or CNS indications, and direct management of high-performing external consultants or agencies.
For candidates based in the SFBA area, the salary range for this position is: $250,000 to $280,000.
For candidates based outside the SFBA area, the salary range is $233,000 to $263,000.
Encoded considers a variety of factors when determining base compensation, including experience, qualifications, internal equity and geographic location. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives, paid time off, and a benefits package.
Benefits
- Comprehensive benefits package, including competitive employer premium contributions
- Meaningful stock option grants
- PTO, sick time, and holiday pay
- Generous Parental Leave program
- Pre-tax medical and dependent care programs
- STD, LTD, Life and AD&D
- Professional development opportunities
- Team-building events
- Fully stocked kitchen
- Fitness center at our SF office
Employees (and their families) may obtain medical, dental, vision and basic life insurance benefits through the company and enroll in our company’s 401k plan. Employees will also accrue vacation time off and paid sick time off and may become eligible for paid parental leave. Employees will also enjoy designated paid holidays throughout the calendar year.
Encoded is an Equal Opportunity Employer and prohibits discrimination and harassment of any kind. Encoded is committed to the principle of equal employment opportunity for all employees and to providing employees with a work environment free of discrimination and harassment. All employment decisions at Encoded are based on business needs, job requirements and individual qualifications, without regard to race, religion or belief, color, national origin, gender, status as a protected veteran, status as an individual with a disability, or any other status protected by the laws or regulations in the location in which we operate. Encoded will not tolerate discrimination or harassment based on any of these characteristics. Encoded encourages applicants of all ages.
If you need assistance or an accommodation due to a disability, you may call us at +1 650-491-0272.